Antibacterial Polyacrylamide and Dextran-Graft-Polyacrylamide Hydrogels for the Treatment of Open Wounds

Background. Open wound treatment requires a use of bandage material to prevent the development pathogenic microflora and provide necessary conditions for tissue regeneration.
 The aim study was compare effectiveness polyacrylamide (PAA) dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (AgNPs), antibiotics, photosensitizers bacterial infection open wounds.
 Materials Methods. PAA D-PAA AgNPs, methylene blue (0.001%) without (MB) red light irradiation (660 nm) (MB+L), chlorhexidine (0.05%) cefuroxime (0.1%) were used. There tested in vitro vivo (a rat model) antibacterial activities against wild-type Staphylococcus aureus, Escherichia coli, antibiotic-resistant coli Klebsiella pneumoniae strains obtained from wound. Clinical investigations performed patients chronic venous ulcers lower extremities no response traditional treatments.
 Results. S. E. K. sensitive chlorhexidine, cefuroxime. Antibiotic-resistant not inhibited by This strain less MB+L. differences between unloaded hydrogels; properties dressing determined an component into hydrogel. helped reduce size 28.6% 42.8% three five days after modeling, respectively. Similar results cefuroxime, hydrogel AgNPs reduced 50% 62.5% induction, respectively, demonstrated greater activity selected clinical investigations. In patient, 14 application, fibrin membrane disappeared, covered pink granulations, marginal epithelialization appeared.
 Conclusions. can be compounds various types. type polymer does affect final hydrogels. MB+L potentially used treat contamination wounds ulcers. Nevertheless, their disadvantage is inability absorb or precipitate breakdown products that interfere normal regeneration inflammation. D-PAA/AgNPs are best option treating due ability control nanoparticles, as well multiple mechanisms action.